Affiliations: [a] Interfaculty Initiative in Information Studies, The University of Tokyo, Bunkyo-ku, Tokyo, Japan | [b] Earthquake Research Institute, The University of Tokyo, Tokyo, Japan | [c] Kanazawa Institute of Technology, Kanazawa, Japan | [d] Institute of Fluid Science, Tohoku University, Sendai, Japan | [e] Research Center for Simulation Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
Correspondence:
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Corresponding author: Futoshi Mori, Interfaculty Initiative in Information Studies, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan. Tel.: +81 3 5841 1768; Fax: +81 3 5841 1768; E-mail: [email protected].
Abstract: Background:Stent placement for cerebral aneurysms leads to a decrease in blood flow. This occurs not only through the direct obstruction of flow but also by the expansion of the parent artery. The latter has been observed in several clinical studies. Objective:The goal of this study was to clarify the effects of parent artery expansion after stent treatment on the following: 1) decrease in blood flow to an aneurysm, 2) wall shear stress (WSS), and 3) oscillatory shear index (OSI). Methods:The parent artery geometry constructed U-shape. The aneurysm location with respect to the U-shaped parent artery was determined according to previous clinical data. We performed calculations in unsteady-state situations using constructed models. Results:Parent artery expansion with stent reduces blood inflow to an aneurysm and WSS of the aneurysm wall, in addition to increasing OSI. The aneurysm position affects the decrease of the inflow rate and WSS ratio and increases the OSI ratio. Expansion causes the majority of effects on flow reduction inside an aneurysm model. Thus, the expansion effects of all samples should not be neglected. Conclusion:These data suggest that parent artery expansion and its effect should be measured and included in the total decrease in blood flow. Parent artery expansion may induce intimal hyperplasia, thus increasing the thickness of the aneurysm wall.
