Prognostic value of procalcitonin (PCT) and/or interleukin-6 (IL-6) plasma levels after multiple trauma for the development of multi organ dysfunction syndrome (MODS) or sepsis

Article type: Research Article

Authors: Haasper, C.^{a; *} | Kalmbach, M.^a | Dikos, G.D.^b | Meller, R.^a | Müller, C.^a | Krettek, C.^a | Hildebrand, F.^a | Frink, M.^a

Affiliations: [a] Trauma Department, Hannover Medical School (MHH), Hannover, Germany | [b] Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

Correspondence: [*] Address for correspondence: Carl Haasper, MD, PhD MS, Hannover Medical School, Trauma Department, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. Tel.: +49 511 532 2050; Fax: +49 511 532 5877; E-mail: [email protected]; http://www.mhh-unfallchirurgie.de.

Abstract: Despite recent advances in treatment of severe injured patients, e.g. due to damage control orthopaedics, multi organ dysfunction syndrome (MODS) and sepsis are major complications in daily practice. During one year 94 patients were prospectively collected. Inclusion criteria: ISS ⩾ 16, age 18–60 y, primary admission to our level-1 trauma center, survival > 48 hours after trauma. The development of MODS and sepsis were observed and different groups were formed (+/-). Demographic data revealed no significant differences between the subgroups. Comparing groups +MODS and −MODS significant differences on admission day were observed, when PCT showed first on day 2 after trauma differences. Regarding the development of sepsis PCT was advantageous to IL-6 showing significant higher plasma levels in group +sepsis from the first day after trauma. Serum levels of IL-6 and PCT could be useful in early identification of high risk patients to develop posttraumatic MODS. For sepsis PCT is the better prognostic factor.

Keywords: Multiple trauma, inflammatory mediators, SIRS, MODS, sepsis, survival, prediction

DOI: 10.3233/THC-2010-0571

Journal: Technology and Health Care, vol. 18, no. 2, pp. 89-100, 2010