Affiliations: [a] Department of Orthopedics and Traumatology, Suleyman Demirel University School of Medicine, Isparta, Turkey | [b] New Technologies Research and Development Center (YTAM), Marmara University, Istanbul, Turkey | [c] Department of Pharmacology, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey | [d] Department of Surgery, Istanbul University School of Veterinary, Istanbul, Turkey
Correspondence:
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Corresponding author: Nurettin Heybeli, M.D., Assistant Professor of Orthopaedics and Traumatology, Address: Posta Kutusu: 128, 32000 Isparta, Turkey. Tel.: +90 246 211 23 11; Fax: +90 246 237 17 62; E-mail: [email protected].
Abstract: Treatment of osteomyelitis with local antibiotic delivery systems has become a common practice in orthopaedic surgery. This study attempted to show that locally produced pure or bioglass reinforced plaster of Paris, hydroxyapatite and sodium alginate are promising biomaterials and mainly because of economical reasons and availability, may be an alternative in clinical practice, especially for developing countries. A total of 32 rabbits were divided into four groups (n:8). In group A, sodium alginate + cephazoline; in group B, plaster of Paris + bioglass + cephazoline; in group C, plaster of Paris + hydroxyapatite + cephazoline and in group D, plaster of Paris + cephazoline were used. The blood serum cephazoline concentrations were analyzed by high performance liquid chromatography on days 1 to 10 everyday and then at days 13, 17, 18, 24, 25 and 30. The mean values ± standard deviations and median values of blood serum antibiotic concentrations for groups A, B, C and D were 1.45 ± 0.40 (1.42) mcg/ml, 1.53 ± 0.64 (1.31) mcg/ml, 1.92 ± 0.39 mcg/ml (1.90) and 1.41 ± 0.65 (1.25) mcg/ml, respectively. The detected antibiotic level was constantly over the minimum inhibitory concentration for Staphylococcus aureus. In conclusion, it can be stated that these materials are promising as a antibiotic delivery system even with simple production methods.
Keywords: osteomyelitis, hydroxyapatite, plaster of Paris, calcium sulfate, sodium alginate, bioglass, local antibiotic delivery
