Abstract: The objectives of this research were to: (1) determine the risk factors in the VDT workstation systems associated with the physical symptoms reported by VDT users; and (2) examine the interrelationship among these risk factors. A research model was developed. A survey was then designed and conducted among 88 computer users. Factor analysis and regression analysis methods were used to analyze the data. Different types of physical symptoms experienced by VDT operators are related to different risk factors. Ocular discomfort is significantly related to screen glare. General musculoskeletal and physical symptoms are related to fatigue and awkward work postures. Upper body symptoms are related to awkward work postures. Psychosocial factors significantly interact with other variables, such as demographic variables, and are associated with awkward work postures and psychological stress. Poor workstation designs are associated with awkward work postures which in turn are related to physical symptoms.