Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Nguyen, Thi Dunga; * | Mai, Bich Dungb; * | Doan, Thi Tama | Vo, Nguyen Thanh Thaoa | Le, Quang Luana | Ha, Thi Loana
Affiliations: [a] Biotechnology Center of Ho Chi Minh City, Ho ChiMinh City, Vietnam | [b] Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Ho ChiMinh City, Vietnam
Correspondence: [*] Corresponding author: Thi Dung Nguyen, Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Vietnam. Tel.: +84935358270; E-mail: [email protected]; ORCID: 0000-0002-1022-3748 and Bich Dung Mai, Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Ho Chi Minh City, Vietnam. Tel.: +84868844320; E-mail: [email protected]; ORCID: 0000-0002-2810-7251.
Abstract: BACKGROUND:Stachys affinis Bunge (S. affinis) tubers are rich in carbohydrate with a large amount of stachyose which had been proven to have antidiabetic potential. OBJECTIVE:The present study aims to evaluate hypoglycemic effects of tuber extract of Stachys affinis in streptozotocin-induced diabetic mice. METHODS:The stachyose content of the extract was determined by UPLC. Diabetes was induced by the administration of single dose of streptozotocin (170 mg/kg). The hypoglycemic effects of the extract were evaluated by comparing fasting blood glucose level, glucose tolerance, insulin sensitivity between groups treated with the S. affinis tuber extract (at doses of 750 mg/kg and 1500 mg/kg) and diabetic control group over 28 days of treatment. RESULTS:The daily treatment with the extract at doses of 750 mg/kg and 1500 mg/kg significantly reduced fasting blood glucose level from 278.12 mg/dL to 127.50 mg/dL, and 238.97 mg/dL to 177.12 mg/dL (p < 0.01), respectively. Besides, the treatment also improved the sensitivity of diabetic treated mice to insulin (P < 0.05). CONCLUSION:The study revealed that the S. affinis tuber extract demonstrated significant hypoglycemic effects.
Keywords: Hypoglycemic, UPLC, Stachyose, Stachys affinis Bunge, Streptozotocin
DOI: 10.3233/MNM-230043
Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 16, no. 4, pp. 313-321, 2023
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]