Affiliations: [a]
Department of Biochemistry and Molecular Biology, Faculty of Science, Usmanu Danfodiyo University, PMB 2346, Sokoto, Sokoto State, Nigeria
| [b]
Department of Internal Medicine, Faculty of Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University Teaching Hospital, PMB 2370, Sokoto, Sokoto State, Nigeria
Correspondence:
[*]
Corresponding author: Dr. R.A. Dogondaji, Department of Biochemistry and Molecular Biology, Faculty of Science, Usmanu Danfodiyo University, PMB 2346, Sokoto, Sokoto State, Nigeria. Tel.: +2348036302001; E-mail: [email protected].
Abstract: Dromedary camels (Camelus dromedarius) inhabit not only arid areas but are among common domestic animals that are normally kept for numerous uses. It’s raw milk (CM) is believed to have exceptional nutraceutical value in addition to it’s other uses similar to camel itself. This study aimed to evaluate hypotensive efficacy of raw CM within context of chemical induced hypertension model in albino rats. Rats received the chemical; L-NAME (50 mg/kg body weight/day, p.o.) and amlodipine (10 mg/kg/day, p.o.) as negative and positive controls for 4 weeks. Rats of treatment group received concurrently L-NAME (50 mg/kg body weight /day, p.o.) and raw milk of camel at (100, 300, and 500 mg/kg body weight/day p.o.) respectively for 4 weeks. Result showed significant decrease (p < 0.001) in treatment relative to negative control in all measured parameters viz systolic, diastolic and mean arterial blood pressures in accordance to the used dosages. Also elevated levels of liver/kidney biomarkers in negative control became reduced compared to normal and positive controls courtesy of CM treatment. In conclusion, obtained data revealed CM to be effective in controlling hypertension. The bioactive constituents present in CM appeared likely to be responsible for the observed effect of antioxidant action and ACE inhibition. Evidence is thus provided from research findings that raw CM can afford efficient hypotensive effect.
Keywords: Raw camel milk (CM), hypotensive, milk composition, ACE inhibition
