Affiliations: [a] Tekirdağ Namık Kemal University, School of Health, Department of Nutrition and Dietetics, Tekirdağ, Turkey | [b] Inonu University, Faculty of Health Sciences, Department of Nutrition an Dietetics, Malatya, Turkey | [c]
Tekirdağ Namık Kemal University, Faculty of Medicine, Department of Medical Biochemistry, Tekirdağ, Turkey
Correspondence:
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Corresponding author: Sergen Tuğgüm, Tekirdağ Namık Kemal University, School of Health, Department of Nutrition and Dietetics, Tekirdağ/Turkey. Tel.: +90 539 981 57 05; E-mail: [email protected].
Abstract: BACKGROUND:Type-2 diabetes with an increasing prevalence is a public health problem. Irisin and vaspin, which are secreted a majority from adipose tissue, are discovered hormones recently, and their effects on diabetes are studied. OBJECTIVE:This study aims to the effects of diet on these hormones levels in diabetic rats. METHODS:In this study, ten-week-old 18 Wistar-Albino rats were divided into three groups randomly. The diabetic group (n = 6) was fed a high-fat diet (HFD). Other rats were divided into two control groups, one of them (n = 6) was fed a control diet (CD), and the other group (n = 6) was fed HFD. The feeding time for all groups was 4 weeks. Streptozotocin (STZ) was used for diabetes induction in rats. RESULTS:At the end of the four weeks, the body weight of the diabetic group decreased significantly. In the diabetic group compared to the control groups, it was observed that besides high fasting blood glucose (FBG), triglyceride, total cholesterol levels, and insulin resistance (HOMA-IR) scores. Vaspin levels were significantly higher in diabetic rats, while irisin levels were similar between groups. Besides, vaspin level correlation with biochemical parameters such as glucose, triglycerides, total cholesterol, and HOMA-IR score was significant. CONCLUSION:In conclusion, this study showed that besides the evidence that vaspine is a hormone associated with diabetes, diet composition could give an opinion about the type-2 diabetes process by looking at hormone levels.
Keywords: Diabetes, irisin, vaspin, nutrition, high fat diet
