Affiliations: [a]
Laboratory of Cell Biology and Molecular Genetics, Faculty of Sciences, Agadir – Morocco | [b] Dietitian – Nutritionist, Health Universe, Agadir – Morocco | [c]
Faculty of medicine and University Hospital Center, Agadir – Morocco | [d]
Medical Biology Department; Hassan II Regional Hospital, Agadir – Morocco | [e]
Higher Institute of Nursing Professions and Health Techniques, ISPITS, Agadir – Morocco | [f] Laboratory of Aquatic Systems, Faculty of Sciences, Agadir – Morocco
Correspondence:
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Corresponding author: Abdellah Moukal, Laboratory of Cell Biology and Molecular Genetics, Faculty of Sciences, Agadir – Morocco. Tel.: +212661210989: E-mail: [email protected].
Abstract: OBJECTIVES:Assessing Vitamin-D status and checking if low serum 25(OH)D is a factor in breast cancer (BC) for Southern Moroccan women. MATERIALS/METHODS:Study conducted in Morocco about women with BC (n = 90) and controls (n = 90). 25-hydroxy-vitamin-D biological analyzes executed during the first consultation. Social data and anthropometric parameters were collected for all participants. RESULTS:Women from urban areas constitued 67.78 % for the cases and 85.6% for the controls. The average age was 48.72±9.71 (cases) and 46.40±12.52 (controls). We found that 53.33% of cases and 40% of controls were postmenopausal and that hypovitaminosis-D affected 80 and 64.4% of cases and controls, respectively. Statistical analysis showed that hypovitaminosis-D was a significative risk factor for BC in Southern Moroccan women. The Odds Ratio was of 5 (p < 0.0001). The BC subtypes had Odds Ratios greater than 1. The highest value was obtained with Luminal B subtype (Odds ratio = 6.25; p = 0.0007). CONCLUSION:This study reinforces the evidence implicating hypovitaminosis-D among modifiable risk factors for BC. Further studies are needed to assess the extent of hypovitaminosis-D in Moroccan women with BC.
Keywords: 25-HydroxyVitamin-D, breast, case-control study, Moroccan population
