Metabolic Syndrome, Homocysteine and uric acid in patients with obesity; experience from Obesity and Work Centre

Article type: Research Article

Authors: Gori, Francesca^a | Tirelli, Amedea Silvia^b | Piontini, Alessandra^{c; d} | De Gennaro Colonna, Vito^{c; e} | Bamonti, Fabrizia^f | Vassalle, Cristina^g | Vigna, Luisella^{c; *}

Affiliations: [a] Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy | [b] Laboratory of Clinical Chemistry and Microbiology, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy | [c] Occupational Health Unit, Center of Obesity and Work, EASO Collaborating Centers for Obesity Management, Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy | [d] Department of Transfusion Medicine and Haematology, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy | [e] Department of Clinical Sciences and Community Health DISSCO, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy | [f] Clinical Chemistry and Biochemistry, University of Milan, Milan, Italy | [g] Fondazione CNR-Regione Toscana ‘G Monasterio’, Pisa, Italy

Correspondence: [*] Corresponding author: Luisella Vigna, Occupational Health Unit, Center of Obesity and Work, EASO Collaborating Centers for Obesity Management, Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, 20122, Milan, Italy. E-mail: [email protected].

Abstract: BACKGROUND:Uric acid (UA) and homocysteine (HCys) are involved in cardiovascular diseases. Patients with obesity (PwO) are characterized by elevated cardiovascular risk. OBJECTIVE:To evaluate the relationship between HCys and UA concentrations in 1141 overweight patients and PwO with and without metabolic syndrome (MS). METHODS:MS was defined according to IDF criteria (2005). Anthropometric data were recorded and blood biochemical parameters were assessed with routine methods on fasting blood samples. Statistics: Spearman correlation and multiple regression analysis. RESULTS:Gender, obesity and MS influenced both UA and HCys levels, which were increased in males, MS patients, PwO with MS and positively correlated (p < 0.001). Patients without MS had normal or slightly high levels. Hypertension, hyperuricemia and hyperhomocysteinemia were found in PwO with MS. UA concentration correlated with systolic blood pressure, triglycerides and HDL (all p < 0.05). Multivariate analysis showed that HCys concentration was an independent determinant factor affecting UA levels (T value 3.5, p < 0.001). CONCLUSIONS:HCys and UA levels positively and significantly correlated in PwO, especially in those with MS. The significant correlation between UA and hypertension, triglycerides, HDL suggests the clinical usefulness of monitoring UA together with HCys concentrations as cardiovascular risk marker in these patients.

Keywords: Obesity, homocysteine, uric acid, metabolic syndrome, cardiovascular risk, cardiovascular disease

DOI: 10.3233/MNM-210554

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 14, no. 3, pp. 277-288, 2021