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Article type: Research Article
Authors: Moradi, Sabaa | Tavilani, Heidarb | Saidijam, Massoudc | Hashemnia, Mohammadd | Vaisi-Raygani, Asade; *
Affiliations: [a] Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran | [b] Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran | [c] Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | [d] Departments of Pathobiology, Veterinary Medicine Faculty, Razi University, Kermanshah, Iran | [e] Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Correspondence: [*] Corresponding author: Asad Veisi-Raygani, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. E-mail: [email protected].
Abstract: BACKGROUND: Liver X receptor α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) as a lipid transporter play an important role in cholesterol efflux from cells. OBJECTIVE: This study was aimed to determine the effect of kiwifruit supplementation on LXRα and ABCA1 gene expressions in liver and intestine of hamsters fed with high-fat diet (HFD). METHODS:36 Golden Syrian male hamsters were divided into 6 groups (n = 6) including, group 1 received chow diet (control normal), group 2 and 3 received chow diet plus 1.86 and 3.73 g/kg kiwifruit, group 4 received HFD, group 5 and 6 received HFD plus 1.86 and 3.73 g/kg kiwifruit for 8 weeks. RESULTS:ABCA1 gene expression were significantly decreased in the liver (p < 0.01) and the intestine (p < 0.05) of HFD group compared with control normal. The gene expression levels of ABCA1 from liver and intestine were increased in HFD treated with kiwifruit compare to untreated HFD group (p < 0.05). LXRα gene expression of intestine was increased in all of the kiwifruit treated groups compared with untreated groups (p < 0.05). CONCLUSIONS:Consumption of kiwifruit in in hamsters receiving HFD can improve cholesterol efflux from liver and intestine by increase the gene expression of ABCA1 and LXRα.
Keywords: Actinidia deliciosa, ATP-binding cassette transporter A1, high-density lipoprotein cholesterol, high-fat diet, liver X receptor α
DOI: 10.3233/MNM-200467
Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 14, no. 4, pp. 343-352, 2021
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