Affiliations: [a] Amasya University Medical School Department of Internal Medicine, Division of Endocrinology and Metabolism, Amasya, Turkey
| [b] Yozgat City Hospital, Department of Endocrinology and Metabolism, Yozgat, Turkey
| [c] Hitit University Erol Olcok Education and Research Hospital, Department of Endocrinology and Metabolism, Corum, Turkey
| [d]
Tokat State Hospital, Department of Endocrinology and Metabolism, Tokat, Turkey
Abstract: OBJECTIVE:There are conflicting results regarding the relationship between metabolic diseases and vitamin D deficiency. We aimed to show the possible relationship between 25-hydroxy (OH) vitamin D levels and obesity, insulin resistance and hyperlipidemia in women. MATERIALS AND METHODS:Three hundred fifty seven female were included retrospectively. Body mass index (BMI) was determined with body weight (kg)/height (m2) formula. Fasting plasma glucose, insulin, lipid profile, calcium, phosphorus, parathormone, 25 hydroxy vitamin D, thyroid stimulating hormone were evaluated. Insulin resistance was calculated with homeostatic model values for insulin resistance (HOMA-IR). Patients were grouped according to 25 (OH) vitamin D levels and BMIs. RESULTS:25 (OH) vitamin D was negative correlated with BMI, insulin and HOMA-IR, (respectively r = –0.156, –0.128, –0.123 and p = 0.003, 0.015, 0.020). It is positive correlated with HDL and HDL/LDL ratio (respectively r = 0.183, 0.185 and p = 0.003, <0.001) HDL-C was higher in 25(OH) vitamin D sufficient group. After multivariate analysis, 25 (OH) vitamin D was still positively related with HDL and HDL/LDL ratio (respectively r = 0.127, 0.118 and p = <0.05). CONCLUSION:25 (OH) Vitamin D is relationship with HDL, HDL/LDL ratio and invers relationship obesity. The normal 25 (OH) vitamin D supports the reduction of metabolik risk.
