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Article type: Research Article
Authors: Mineri, Rossanaa | Ghilardi, Giosuèb | Brambilla, Simonaa | Sarno, Tizianaa | Bologna, Muriela | Valaperta, Serenellaa | Montanelli, Alessandroa
Affiliations: [a] IRCCS, Istituto Clinico Humanitas, Clinical Investigation Laboratories, Via Manzoni, 20089 Rozzano (MI), Italy. e-mail: [email protected] | [b] Diabetology and Endocrinology Unit, Ospedale S. Biagio di Clusone, A.O. Bolognini, Seriate (BG), Italy
Abstract: Lactose intolerance is found in 70% of the world-wide population. Lactase activity gradually increases till birth and then, after the early months of life, it physiologically begins to lessen. In about 30% of the population it remains active also as an adult due to a mutation: in Europe a substitution of C with T in position 13910 of the lactase gene. Our data show that CC genotype, associated with lactase non-persistence, is found in type 1 diabetes with a high prevalence of 67%. To evaluate the “glycaemic-metabolic control” we investigated the glycosylated haemoglobin (HbA1c) values and we noted that there is no significant difference between CC (non-absorber) and CT/TT (absorber) genotypes of diabetic patients. Glutamic acid decarboxylase antibodies (GADA) are positive in 58% of diabetic patients with CC genotype: this presence could be linked to the intestinal membrane hyperpermeability.
Keywords: Lactose intolerance, Lactase persistence, Diabetes, C/T (13910)
DOI: 10.3233/s12349-008-0027-y
Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 1, no. 3, pp. 181-185, 2009
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