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Hepatoprotective effect of aqueous and pure extracts of raisin in alloxan-induced diabetic rats

Article type: Research Article

Authors: Ghrairi, Fatmaa | Lahouar, Lamiab | El Arem, Amirab | Mokni, Monsefc | Achour, Lotfib | Said, Salema

Affiliations: [a] Laboratory of Biochemistry, Faculty of Medicine Sousse, Sousse, Tunisia | [b] Laboratory of Bioressources, Biologie Integrative and Valorization, Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia | [c] Department of Histopathology-Cytopathology, Division of Pathology, Faculty of Medicine, Farhat Hached University Hospital, Sousse, Tunisia

Correspondence: [*] Corresponding author: Fatma Ghrairi, Laboratory of Biochemistry, Faculty of Medicine Sousse, Mohamed Karoui Avenue, 99/UR/08-45, 4002 Sousse, Tunisia. Fax: +216 7322 4899; E-mail: [email protected]

Keywords: “Karkni”, alloxan, liver, antioxidant enzymes, MDA

DOI: 10.3233/MNM-130004

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 7, no. 1, pp. 45-53, 2014

Received 14 June 2013
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Accepted 21 November 2013
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Published: 1 January 2014
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Abstract

The present study was conducted to evaluate the possible antioxidant effects of raisin aqueous and pur extract of “Karkni” on liver histology, antioxidant enzymes activities and lipid peroxide levels in liver of diabetic and normal rats. 125 mg/kg of pure and aqueous extract of “Karkni” were orally administered daily to alloxan-diabetic rats for 4 weeks. Alloxan- induced diabetic rats showed significant increases in the levels of total protein and malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT) and reduced glutathione (GSH) levels were significantly decreased compared to normal rats (p < 0.05). Also, no significant effects on glutathione peroxidase (GPx) activity in diabetic rats were observed. The changes of the above parameters to their normal levels after 4 weeks of treatment were observed mainly with the pure extract. The results suggesting that pure extract suppresses the liver tissue inflammation attenuate lipid peroxidation and can be helpful in reducing liver damage caused by alloxan-induced diabetes.

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