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The effect of date palm fruit (Phoenix dactylifera L.) on the hormone 17-ß-estradiol in 7,12-dimethylbenz(a)anthracene-induced mammary cancer in rats

Article type: Research Article

Authors: Al-Sayyed, Hiba F.a; * | Takruri, Hamed R.a | Shomaf, Maha S.b | Al-Saleh, AbdulRahmanc

Affiliations: [a] Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Amman, Jordan | [b] Department of Pathology and Microbiology and Forensic Medicine, Faculty of Medicine, The University of Jordan, Amman, Jordan | [c] Division of Food Microbiology, Department of Food Laboratories, Directory of Laboratories, Jordan Food and Drug Administration, Amman, Jordan

Correspondence: [*] Corresponding author: Hiba F. Al-Sayyed, Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Amman, Jordan. E-mail: [email protected]

Keywords: Date palm fruit, 17-ß-estradiol, 7,12-dimethylbenz(a)anthracene-induced mammary cancer, sprague dawley rats

DOI: 10.3233/MNM-140001

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 7, no. 1, pp. 5-10, 2014

Received 21 September 2013
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Accepted 28 November 2013
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Published: 1 January 2014
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Abstract

The effect of date palm fruit feeding (to female Sprague-Dawley rats with 7,12-dimethylbenz(a)anthracene–induced mammary cancer) on the hormone 17-ß-estradiol concentration was compared to that of feeding soybean seeds and injection with two drugs (one preventive against and the other curative for 7,12-dimethylbenz(a)anthracene-induced mammary cancer i,e. tamoxifen and the hormone 17-ß-estradiol). The date palm fruit raised the hormone concentration significantly (p < 0.05). The hormone concentration was positively correlated with the palpable tumor latency, and negatively correlated with tumor incidence rate and multiplicity. It is concluded that the preventive effect of the date palm fruit against 7,12-dimethylbenz(a)anthracene-induced mammary cancer is related to the effect on the hormone 17-ß-estradiol.

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