Affiliations: [a] Department of Chemistry, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
| [b] Department of Chemistry, Faculty of Sciences, Kerman branch, Islamic Azad University, Kerman, Iran
Correspondence:
[*]
Corresponding author: Z. Rashidi Ranjbar, Department of Chemistry, Shahid Bahonar University of Kerman, 22
Bahman Blvd, PO BOX 76961, Kerman, Iran. Tel./Fax: +98 3433222033; E-mail: [email protected].
Abstract: The present research investigates the size effect of Deferasirox, “4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1yl]-benzoicacid”, to reduce lead(II) poisoning in rat bodies. The lead(II) ions as PbCl2 was given orally to the rats in 40 mg/kg dose for 100 days. Deferasirox in nano scale was prepared by sonochemistry method. The effects of initial substance (0.025, 0.05 and 0.1 g) and reaction time (15, 30 and 45 min) on deferasirox size were investigated. Chemotherapy by deferasirox in two scales, nano (16 nm) and bulk (6 μm), was done during 15 days. The lead(II) concentration in various tissues such as heart, liver, spleen and kidneys was determined by graphite furnace atomic absorption spectroscopy (GFAAS). The results show by decreasing in deferasirox particle size; more lead(II) amount were removed from rat’s organs.
