Affiliations: Material and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
Correspondence:
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Corresponding author: Saeed Kakaei, Material and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran. E-mail: [email protected].
Abstract: Herein, a significantly improved synthesis and purification of synthesis of Baclofen via dissolving β-(para-chlorophenyl)-glutaric acid imide into basic solution and further amount of bromine to access Baclofen with high purity is reported. pH of the reaction solution was adjusted with concentrated hydrochloric acid. Finally, the 4-amino-3-(4- chlorophenyl) butanoic acid was filtered and recrystallized. It is demonstrated that the present synthetic protocol doesnot need any hazardous or harmful solvents, has operational simplicity, and shows high yields and short synthetic route with simple work-up. As an advantage, this method includes a convenient approach for synthesis of Baclofen with ultrasound irradiation as the convenient energy source at the first step of reaction Followed by leading to good production yeilds. The product was characterized by M.p, IR, and NMR.
