Microwave assisted solvent free one pot synthesis of acenaphtho [1,2-d] imidazole derivatives using NH₄⁺ OAc^– / NH₄⁺Cl ^–

Article type: Research Article

Authors: Mohammadi, Mohammad Kazem^{; *}

Affiliations: Advanced Surface Engineering and Nano Materials Research Center, Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

Correspondence: [*] Corresponding author: Mohammad Kazem Mohammadi, Advanced Surface Engineering and Nano Materials Research Center, Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. E-mail:[email protected].

Abstract: A novel, highly efficient, eco-friendly, and quick microwave-assisted synthesis of 2, 4, 5- substituted imidazoles by one-pot cyclo condensation of acenaphthoquinone, aromatic aldehydes, and ammonium acetate was reported under solvent-free conditions using ammonium chloride as a catalyst with excellent yield. The present methodology offers several advantages, such as mild reaction conditions, easy workup, short reaction time, excellent yield, purification of products by the non-chromatographic method, and reproducibility in large-scale synthesis. Compounds were characterized by IR, 1HNMR, 13C NMR spectroscopy and their melting points were compared with the literature reports.

Keywords: One-pot, synthesis, imidazole, microwave, solvent-free

DOI: 10.3233/MGC-230073

Journal: Main Group Chemistry, vol. Pre-press, no. Pre-press, pp. 1-8, 2024