Azidation of aryl halides promoted by EDTA

Article type: Research Article

Authors: Rezapour, Mehdi^{a; b} | Ghorbani, Sirous^a | Khodabakhshi, Mohammad Reza^{a; *} | Abbasi, Mohammad^b

Affiliations: [a] Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Mollasadra Street, Tehran, Iran | [b] Persian Gulf University: Bushehr, Bushehr, Iran

Correspondence: [*] Corresponding author: Mohammad Reza Khodabakhshi, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Mollasadra Street, Tehran, Iran. E-mail: [email protected].

Abstract: An efficient approach to azidation of aryl halides is described here. Good yields of aryl azides were obtained with [CuI/EDTA]–3 as a catalytic system. Cost-affectivity of the EDTA compared to expensive DMEDA (1 : 500 times) along with the use of 7EtOH:3H2O as mixed solvent and green medium makes it to be a suitable method for selective synthesis of aryl azides.

Keywords: Aryl azide, EDTA, DMEDA

DOI: 10.3233/MGC-210031

Journal: Main Group Chemistry, vol. 20, no. 3, pp. 263-267, 2021