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Lewis Base Catalyzed Trifluoromethylation of Carbonyl Compounds with Trialkyl(trifluoromethyl)silanes

Article type: Research Article

Authors: Hagiwara, Toshiki | Kobayashi, Toshinori | Fuchikami, Takamasa

Affiliations: Sagami Chemical Research Center, Nishi-Ohnuma 4-4-1, Sagamihara, Kanagawa 229, Japan

Abstract: Many Lewis bases effectively catalyze the trifluoromethylation of carbonyl compounds with trimethyl(trifluoromethyl)silane. By using chiral Lewis bases as catalysts, asymmetric trifluoromethylation was achieved. The higher enantiomer excesses were observed on using trialkyl(trifluoromethyl)silanes bearing bulky alkyl groups on the silicon atom.

DOI: 10.1080/13583149712331338829

Journal: Main Group Chemistry, vol. 2, no. 1, pp. 13-15, 1997

Received 27 September 1996
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Published: 1997
Price: EUR 27.50
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