A Comparison of the Potent in vitro Antitumor Activity of Triphenyltin Benzoates with that of Related Tin Compounds

Article type: Research Article

Authors: Tranter, Carolyn J. | Price, Susan J. Berners | Cutts, Janelle | Parsons, Peter G. | Rintoul, Gavin | Young, David J.

Affiliations: Faculty of Science and Technology, Griffith University, Nathan, 4111 Australia | Queensland Institute of Medical Research, Herston, 4029, Australia

Note: [] Corresponding author.

Note: [] Corresponding author.

Abstract: A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.

DOI: 10.1080/13583149512331338375

Journal: Main Group Chemistry, vol. 1, no. 1, pp. 165-167, 1995