Article type: Research Article
Authors: El-Tabl, Abdou S. | Abd El-Waheed, Moshira M. | Shakdofa, Mohamad M.E.; | Abou El-Fadl, Nahla A.
Affiliations: Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt | Department of Pathology, Faculty of Medicine, El-Menoufia University, Shebin El-Kom, Egypt | Department of Chemistry, Faculty of Science and Arts, Khulais, King Abdulaziz University, Saudi Arabia | Inorganic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt
Note: [] Corresponding author: Abdou S. El-Tabl, Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt. E-mail: [email protected]
Abstract: A new series of manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) cadmium(II) and mercury(II) complexes of N′-(3-(hydroxyimino)-4-oxopentan-2-ylidene) isonicotinoylhydrazide (H2L) have been prepared and characterized by elemental and thermal (DTA and TGA) analyses, IR, UV-VIS, 1H-NMR, ESR, mass spectroscopy, magnetic susceptibility, and conductivity. Molar conductance in DMF solution indicated that the complexes are nonelectrolytes. IR spectral data showed that the ligand is either neutral bidentate, (4), neutral tridentate, (3) and (12) or monobasic tridentate (2), (5)-(11). The ESR spectra of solid copper(II) complexes (2), (4), (11) and (12) showed g‖ > g⊥ > ge, indicating a distorted octahedral structure and the presence of the unpaired electron in a d(x2-y2) orbital. However, copper(II), manganese(II) and cobalt(II) complexes (3), (6) and (8), respectively, had isotropic spectra. Complexes (2), (3), (4), (5), (7), (11) and (12) demonstrated potential antiproliferative activity against the growth of human breast cancer tumor cell line MCF-7.
Keywords: Isonicotinoyl hydrazide, hydrazoneoxime, metal complexes, antitumor, ESR
DOI: 10.3233/MGC-130099
Journal: Main Group Chemistry, vol. 12, no. 2, pp. 153-168, 2013
