Synthesis, spectral characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff bases derived from 3-formyl quinoline and 2,6-diaminopyridine and their biological studies
Affiliations: Department of Chemistry, Karnataka University's Karnatak Science College, Dharwad, Karnataka, India | Department of Chemistry, Laxmi Venktesh Desai College, Raichur, Karnataka, India | Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India | Department of Medicinal Chemistry, Luqman College of Pharmacy, Gulbarga, Karnataka, India | Department of Chemistry, KLE Society's P. C. Jabin College, Hubli, Karnataka, India
Note: [] Corresponding author: Shreedhar D. Dhumwad, Department of Chemistry, Karnataka University's Karnatak Science College, Dharwad-580 001, Karnataka, India. Tel.: +91 9449188294; E-mail: [email protected]
Abstract: A series of Schiff bases derived from 2-mercapto-3-formyl quinoline/2-hydroxy-3-formyl quinoline with 2,6-diaminopyridine (DAP) and their corresponding transition metal complexes were synthesized, characterized by elemental analysis, spectral (IR, 1H-NMR, Mass, UV-Vis, Fluorescence, ESR, TGA) and magnetic studies. The molar conductances in DMF solution indicated that the complexes were non-electrolytic. The Schiff bases and their metal complexes were screened for analgesic, anti-inflammatory and antipyretic activities. Among all the compounds, the copper complexes had the greatest pharmacological activities.
