Synthesis, characterization and DNA interaction of the transition metal complexes with 2-formyl furan-derived aroylhydrazones

Article type: Research Article

Authors: Gökçe, Cansu | Gup, Ramazan

Affiliations: Department of Chemistry, Mugla Sıtkı Koçman University, Kotekli-Mugla, Turkey

Note: [] Corresponding author: Ramazan Gup, Department of Chemistry, Mugla Sıtkı Koçman University, 48000 Kotekli-Mugla, Turkey. E-mail: [email protected]

Abstract: In the present work two new aroylhydrazones bearing furan ring 4-N′-[(Z)-furan-2-ylmethylidene]-4-hydroxybenzohydrazide (HL1) and hydroxymethyl (4-{[(2Z)-2- (furan-2-ylmethylidene)hydrazinyl]carbonyl}phenoxy)acetate (HL2) and their Cu(II), Ni(II) and Zn(II) complexes were synthesized and characterized. DNA binding and DNA cleavage activities of both aroylhydrazone ligands and their transition metal complexes were examined by using UV-vis titration and agarose gel electrophoresis in the presence of H2O2. The results indicate that all the copper complexes bind slightly to calf thymus DNA and effectively cleave pBR322 DNA whereas the nickel and zinc complexes have only slight interactions with DNA.

Keywords: Aroylhydrazone, metal complexes, DNA-binding and cleavage

DOI: 10.3233/MGC-130087

Journal: Main Group Chemistry, vol. 12, no. 1, pp. 25-38, 2013