Affiliations: [a]
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
| [b] Department of Physics and Reconstruction, Molecular Imaging Business Unit, United Imaging Healthcare Co., Ltd, Shanghai, China | [c]
Divisions of Thoracic and Cardiac Imaging at Massachusetts General Hospital
Correspondence:
[*]
Corresponding author: Ge Wang, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. E-mail: [email protected].
Note: [1] Q. Yang and Y. Lu are in co-first authorship.
Abstract: In a typical positron emission tomography/computed tomography (PET/CT) system, the attenuation correction is necessary for PET image reconstruction, which involves a transformation from the CT Hounsfield units (HU) to its linear attenuation coefficient (LAC) at 511 keV. This transformation is usually aided by an empirical bilinear function, followed by the forward projection of the transformed attenuation image. In this paper, we propose a direct method that calculates attenuation factors from CT projections, without using a reconstructed CT image. In this method, the human body is considered as a mixture of three distinct components: air, water and bone. Then, we estimate the proportions of these three components along each x-ray path and restore the attenuation factor at 511 keV with the known water and bone LACs. Our numerical results show that the proposed method produces as accurate estimation as the conventional HU mapping method.
