Dosimetry and treatment efficiency of SBRT using TaiChiB radiotherapy system for two-lung lesions with one overlapping organs at risk

Article type: Research Article

Authors: Duan, Yanhua^{a; b} | Feng, Aihui^{a; b} | Wang, Hao^a | Chen, Hua^a | Gu, Hengle^a | Shao, Yan^a | Huang, Ying^a | Shen, Zhenjiong^a | Kong, Qing^{a; *} | Xu, Zhiyong^{b; *}

Affiliations: [a] Institute of Modern Physics, Fudan University, Shanghai, China | [b] Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Correspondence: [*] Correspondening authors. Zhiyong Xu, Institute of Modern Physics, Fudan University, Shanghai, China. Tel.: +86 18017321780; E-mail: [email protected]. and Qing Kong, Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Tel.: +86 18049847626; E-mail: [email protected].

Abstract: Purpose:This study aims to assess the dosimetry and treatment efficiency of TaiChiB-based Stereotactic Body Radiotherapy (SBRT) plans applying to treat two-lung lesions with one overlapping organs at risk. Methods:For four retrospective patients diagnosed with two-lung lesions each patient, four treatment plans were designed including Plan Edge, TaiChiB linac-based, RGS-based, and a linac-RGS hybrid (Plan TCLinac, Plan TCRGS, and Plan TCHybrid). Dosimetric metrics and beam-on time were employed to evaluate and compare the TaiChiB-based plans against Plan Edge. Results: For Conformity Index (CI), Plan TCRGS outperformed all other plans with an average CI of 1.06, as opposed to Plan Edge′s 1.33. Similarly, for R50 %, Plan TCRGS was superior with an average R50 % of 3.79, better than Plan Edge′s 4.28. In terms of D2 cm, Plan TCRGS also led with an average of 48.48%, compared to Plan Edge′s 56.25%. For organ at risk (OAR) sparing, Plan TCRGS often displayed the lowest dosimetric values, notably for the spinal cord (Dmax 5.92 Gy) and lungs (D1500cc 1.00 Gy, D1000cc 2.61 Gy, V10 Gy 15.14%). However, its high Dmax values for the heart and great vessels sometimes exceeded safety thresholds. Plan TCHybrid presented a balanced approach, showing doses comparable to or better than Plan Edge without crossing safety limits. In terms of beam-on time, Plan TCLinac emerged as the most efficient treatment option in three out of four cases, followed closely by Plan Edge in one case. Plan TCRGS, despite its dosimetric advantages, was the least efficient, recording notably longer beam-on times, with a peak at 33.28 minutes in Case 2. Conclusion:For patients with two-lung lesions treated by SBRT whose one lesion overlaps with OARs, the Plan TCHybrid delivered by TaiChiB digital radiotherapy system can be recommended as a clinical option.

Keywords: SBRT, TaiChiB, two-target lung lesions, rotating gamma system, Edge linac, hybrid plan

DOI: 10.3233/XST-230176

Journal: Journal of X-Ray Science and Technology, vol. 32, no. 2, pp. 379-394, 2024