Preoperative prediction of histologic grade in invasive breast cancer by using contrast-enhanced spectral mammography-based radiomics

Article type: Research Article

Authors: Mao, Ning^{a; 1} | Jiao, Zimei^{b; 1} | Duan, Shaofeng^c | Xu, Cong^{d; *} | Xie, Haizhu^{a; *}

Affiliations: [a] Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, P. R. China | [b] Department of Radiology, Yantaishan Hospital, Shandong, P. R. China | [c] GE Healthcare, China, Shanghai, P. R. China | [d] Physical Examination Center, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, P. R. China

Correspondence: [*] Corresponding authors: Haizhu Xie, MD, PhD, and Cong Xu, MD, Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, 20 Yuhuangding Eeast Road, Yantai, Shandong, 264000, China. Tel.: +86 535 6691999; E-mail: [email protected] (Haizhu Xie), [email protected] (Gong Xu).

Note: [1] Ning Mao, Zimei Jiao are co-first authors.

Abstract: OBJECTIVE:To develop and validate a radiomics model based on contrast-enhanced spectral mammography (CESM), and preoperatively discriminate low-grade (grade I/II) and high-grade (grade III) invasive breast cancer. METHOD:A total of 205 patients with CESM examination and pathologically confirmed invasive breast cancer were retrospectively enrolled. We randomly divided patients into two independent sets namely, training set (164 patients) and test set (41 patients) with a ratio of 8:2. Radiomics features were extracted from the low-energy and subtracted images. The least absolute shrinkage and selection operator (LASSO) logistic regression were established for feature selection, which were then utilized to construct three classification models namely, low energy, subtracted images and their combined model to discriminate high- and low-grade invasive breast cancer. Receiver operator characteristic (ROC) curves were used to confirm performance of three models in training set. The clinical usefulness was evaluated by using decision curve analysis (DCA). An independent test set was used to confirm the discriminatory power of the models. To test robustness of the result, we used 100 times LGOCV (leave group out cross validation) to validate three models. RESULTS:From initial radiomics feature pool, 17 and 11 features were selected for low-energy image and subtracted image, respectively. The combined model using 28 features showed the best performance for preoperatively evaluating the histologic grade of invasive breast cancer, with an area under the curve, AUC = 0.88, and 95%confidence interval [CI] 0.85 to 0.92 in the training set and AUC = 0.80 (95%CI 0.67 to 0.92) in the test set. The mean AUC of LGOCV is 0.82. CONCLUSIONS:CESM-based radiomics model is a non-invasive predictive tool that demonstrates good application prospects in preoperatively predicting histological grade of invasive breast cancer.

Keywords: Breast cancer, histologic grade, contrast-enhanced spectral mammography, radiomics, preoperative prediction

DOI: 10.3233/XST-210886

Journal: Journal of X-Ray Science and Technology, vol. 29, no. 5, pp. 763-772, 2021