Affiliations: School of Biomedical Engineering and Sciences,
Virginia Tech, Blacksburg, VA, USA | School of Electrical and Computer Engineering,
University of Oklahoma, Norman, OK, USA
Note: [] Corresponding author: Ge Wang, School of Biomedical Engineering
and Sciences, Virginia Tech, Blacksburg, VA, USA. Tel.: +1 540 231 0620;
E-mail: [email protected]
Abstract: In this paper, we presented a new design of x-ray fluorescence CT
imaging system. For detecting fuorescence signals of gold nanoparticles
in-vivo, multiple spectroscopic detectors are arranged and rotated
orthogonal to an excited region of interest so that a localized scan can be
acquired with a maximized efficiency. Excitation filtration was employed to
minimize the effects of low-energy x-rays and background scattering for
lowering radiation dose to the object. Numerical simulations showed that the
radiation dose is less than 300 mGy/second for a complete 30 views tomographic
scan; and the sensitivity of 3D fluorescence signal detection is up to 0.2%
contrast concentrations of nanoparticles. The x-ray fluorescence computed
tomography is an important molecular imaging tool. It can be used directly in
samall animal research. It has great translational potential for future
clinical applications.
