Coherent Raman protocol of biosensing with a hollow photonic-crystal fiber

Issue title: Nanostructure Glass Technology for X-Ray Optics and Biophotonice

Article type: Research Article

Authors: Konorov, S.O. | Fedotov, A.B.^; | Mel'nikov, L.A. | Shcherbakov, A.V. | Miles, R.B. | Zheltikov, A.M.^;

Affiliations: Physics Department, M.V. Lomonosov Moscow State University, Vorob'evy gory, 119992 Moscow, Russia | International Laser Center, M.V. Lomonosov Moscow State University, Vorob'evy gory, 119992 Moscow, Russia | N.G. Chernyshevsky Saratov State University, ul. Moskovskaya 155, 410026 Saratov, Russia | Institute of Glass Structure Technology and Equipment, pr. Stroitelei 1, 410044 Saratov, Russia | Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, 08544-5263 USA

Note: [] Corresponding author. E-mail: [email protected]

Abstract: A nonlinear-optical protocol of biosensing is demonstrated with a hollow-core photonic-crystal fiber. This protocol involves phase-matched four-wave mixing of millijoule nanosecond laser pulses guided by photonic band gaps of hollow fibers with a two-dimensionally periodic cladding and a core diameter of about 50 μm. Raman resonances related to the stretching vibrations of water molecules inside the hollow fiber core are detected in the spectrum of the four-wave mixing signal, suggesting phase-matched coherent anti-Stokes Raman scattering in hollow photonic-crystal fibers as a convenient sensing technique for condensed-phase biospecies adsorbed on the inner fiber walls and trace gas detection, including exhale-gas diagnostics.

Keywords: Photonic-crystal fibers, biosensing, nonlinear optics, coherent anti-Stokes Raman scattering

Journal: Journal of X-Ray Science and Technology, vol. 13, no. 4, pp. 163-169, 2005