Affiliations: Department of Veterinary Clinical Sciences, College of
Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA and the
Department of Physics and Engineering (WRC), University of Central Oklahoma,
Edmond, OK, USA
Note: [] Corresponding author: Dr. Michael D. Lucroy, Department of
Veterinary Clinical Sciences, 001 BVMTH, Oklahoma State University, Stillwater,
OK 74078, USA
Abstract: Indocyanine green (ICG), with spectral absorption at 800--810 nm, is
a chromophore that strongly absorbs and converts near-infrared laser energy
into thermal energy. By directly injecting ICG into a tumor, selective tumor
hyperthermia during laser irradiation occurs. In this study, 4 dogs with
spontaneous tumors were injected in situ with a 0.25% energy. Thermal data were
collected from multiple thermocouples placed within the tumor and tumor
response was recorded. Tissue heating to ≥ 42°C was observed in all
tumors. One dog had a complete remission, one dog had stable disease for 12
weeks, and the other 2 dogs developed progressive disease shortly after
treatment. Results from this study demonstrate that chromophore-enhanced
laser-induced hyperthermia can effectively and selectively heat canine tumors.
However, tumor size and pigmentation of overlying skin are potentially limiting
factors to the success of this novel c ancer treatment.
