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Susceptibility weighted imaging in a case of lissencephaly: Evidence of persistent fetal vasculature

Article type: Other

Authors: Hegde, Vinay S. | Saini, Jitender; | Ram, Ananta | Sabharwal, Paramveer S. | Bindu, Parayil S.

Affiliations: Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India | Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India

Note: [] Corresponding author: Dr. Jitender Saini, DM, Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560029, India. Tel.: +91 80 26560024; +91 948 082 9654; Fax: +91 80 26564830; E-mail: [email protected].

Keywords: Lissencephaly, susceptibility weighted imaging, persistent fetal vasculature

DOI: 10.3233/PNR-14092

Journal: Journal of Pediatric Neuroradiology, vol. 3, no. 2, pp. 87-90, 2014

Received 24 March 2013
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Revision received 28 May 2013
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Accepted 9 June 2013
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Published: 2014
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Abstract

Lissencephaly, with posterior-anterior gradient, are congenital brain malformations characterized by the presence of a few broad, flat gyri with thickened cortex. It results from the arrest of neuronal migration in early gestation. Magnetic resonance imaging (MRI) findings are characteristic and show thickened dysplastic cortex with a paucity of gyri and sulci. We report a case of lissencephaly with posterior-anterior gradient with unique imaging findings on susceptibility weighted imaging. Susceptibility weighted imaging revealed prominent venous channels traversing the thickened cortex. These channels possibly represent primitive vessels, similar to those seen in early cortical development, and can probably be seen due to the enormously thickened cortex in case of lissencephaly.