Affiliations: Department of Neurology, University of Southern California, Los Angeles, CA, USA | Department of Pediatrics, University of Southern California, Los Angeles, CA, USA | Department of Radiology, University of Southern California, Los Angeles, CA, USA | University of California, Los Angeles Stroke Center, University of California Los Angeles, Los Angeles, CA, USA
Note: [] Corresponding author: Waimei Amy Tai, LAC+USC Medical Center, 1100 N State St, A4E117, Los Angeles, CA 90033, USA. Tel.: +1 323 409 4535; Fax: +1 323 441 8937; E-mail: [email protected].
Abstract: Pediatric stroke is particularly challenging because of its variable presentation and relative rarity. Diagnosis of pediatric stroke is often delayed while other diagnoses are considered, unfortunately leading to a loss of therapeutic opportunity. Recent research advances in adult stroke such as multimodal imaging and a clinical trial showing benefits in extending the therapeutic window for thrombolytics are likely to have important implications in pediatric stroke. We describe the case of a 13-year-old boy presenting with acute stroke where multimodal magnetic resonance imaging with perfusion and permeability images allowed safe treatment with thrombolysis outside the standard treatment time window.
Keywords: Multimodal MRI, thrombolysis, stroke, children
