Thrombolysis with rt-PA for an ischemic stroke in boy treated with Fontan operation

Article type: Research Article

Authors: Bianco, Mariangela | Simionato, Franco | Giusti, Cristina | Corea, Francesco | Giua, Alessandra | Martinelli, Vittorio | Comi, Giancarlo | Sessa, Maria

Affiliations: Department of Neurology, San Raffaele Hospital, Milan, Italy | Department of Pediatric Neuroradiology, San Raffaele Hospital, Milan, Italy | Department of Rehabilitation, San Giovanni Battista Hospital, Foligno, Italy | Department of Neurology, University of Sassari, Sassari, Italy

Note: [] Correspondence: Dr. Mariangela Bianco, Neurology Department, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milan, Italy. Tel.: +39 02 2643 3092; Fax: +39 02 2643 2813; E-mail: [email protected]

Abstract: We first report the case of a 14-year-old boy, previously treated with a modified Fontan operation at the age of 2, who underwent an intra-arterial thrombolysis for an ischemic stroke with a favorable outcome. No controlled randomized trials on thrombolysis among childhood stroke have been conducted yet. This and other similar cases suggest that thrombolysis may also be safe and beneficial in pediatric patients and those cases may benefit from a prompt access to specialized stroke centers.

Keywords: Ischemic stroke, Fontan operation, thrombolysis, recombinant tissue plasminogen activator

DOI: 10.3233/JPN-2012-0516

Journal: Journal of Pediatric Neurology, vol. 9, no. 4, pp. 497-500, 2011