Affiliations: Department of Pediatrics, Dr. Sami Ulus Children's
Hospital, Ankara, Turkiye
Note: [] Correspondence: Dr. Ali Bay, Dr. Sami Ulus Children's
Hospital, Babur caddesi, Altındag, Ankara, Turkiye. Tel.: +31 23056063; Fax:
+31 23175313; E-mail: [email protected]
Abstract: Intrathecal chemotherapy and systemic chemotherapy are used for both
prophylaxis and treatment of central nervous system disease in hematologic
malignancies. We presented two children with urinary retention due to
neurotoxicity with two distinct drugs and reasons. The main presenting
complaints were urinary retention and incontinence in both patients. Before the
adverse clinical event, the patients had received vincristine intravenously and
triple therapy with hydrocortisone, cytosine arabinoside, and methotrexate
intrathecally. The clinical event resolved, and vincristine and intrathecal
chemotherapy were deleted from the patients subsequent therapy until recovery
was achieved.
