Cerebral venous thrombosis in child with nephrotic syndrome: A case report

Article type: Research Article

Authors: Hussain, Nahin | Chieng, Siik Kwong | Rickett, Andrew | Gosalakkal, Jayprakash

Affiliations: Department of Pediatric Neurology, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK

Note: [] Correspondence: Nahin Hussain, M.D., Department of Pediatric Neurology, Leicester Royal Infirmary, Leicester LE1 5WW, UK. Tel.: +44 11 62739491; Fax: +44 11 62585631; E-mail: [email protected]

Abstract: Cerebral sinovenous thrombosis (CSVT) is a rare and under-diagnosed complication of childhood nephrotic syndrome. With the advent of magnetic resonance imaging and magnetic resonance venography scans, CSVT cases are now being diagnosed more frequently. We report case of a three-year-old male child, known case of steroid responsive nephrotic syndrome, who presented with a 3-week history of headache and sudden onset intermittent convergent squint. He was diagnosed to have CSVT on magnetic resonance imaging and magnetic resonance venography of the brain. Devastating cerebral infarction was probably prevented with early institution of low molecular weight heparin. Nevertheless, randomized placebo-controlled studies are necessary for assessing its efficacy and absence of risk in children.

Keywords: Venous thrombosis, cerebral, nephrotic syndrome

Journal: Journal of Pediatric Neurology, vol. 5, no. 4, pp. 327-330, 2007