Affiliations: Clinical Student Research Committee, Faculty of
Medicine, Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran | School of Medicine, Zahedan University of Medical
Sciences, Zahedan, Iran | Young Researchers Club, School of Medicine, Islamic
Azad University, School of Medicine, Tonekabon Branch, Iran
Note: [] Correspondence: Mohsen Jamshir, Clinical Student Research
Committee, 5th azar hospital, Golestan University of Medical Sciences, Gorgan,
Iran. Tel.: +98 912 5041395; Fax: +1711192168; E-mail: [email protected]
Abstract: The antibiotic resistance or susceptibility patterns of common
bacterial pathogens vary between geographical regions. We investigated the
antibiotic resistance pattern of common uropathogens in a population of young
children. In this cross- sectional retrospective study, children suspected of
having urinary tract infection (UTI) that were referred to Taleghani Pediatric
Hospital from March 2009 until March 2010 were included. Urine cultures were
performed before initiation of antibiotics. Demographic information and results
of cultures and antibiograms were obtained from the laboratory archive.
Cultures with colony count ⩾ 105 cfu/ml in midstream urine samples or any
colony count in the suprapubic samples were considered to be positive.
Antimicrobial susceptibility testing was performed using the Kirby Bauer disc
diffusion method. We evaluated 7844 urine cultures of which 153 (2%) were
obtained from supra-pubic aspiration route. 3839 (48.9%) were male. In total,
533 (6.8%) of cultures were positive (64.2% were female). E. coli was the
most common organism in positive samples in both sexes, but it was
significantly more common in the females than males (83.3% vs. 75.4%, P
< 0.05). E. coli showed the highest percentage of resistance to ampicillin
(84.1%) and the lowest resistance to amikacin (11%). We found that E. coli was
the predominant bacterial pathogen and that the antimicrobial resistance
patterns of the different uropathogens were highly variable, emphasizing the
importance of continuous surveillance of trends in resistance patterns of
uropathogens.
Keywords: Drug resistance, anibiotics, urinary tract infection, children
