Rosai-Dorfman Disease: An unusual cause of fever of unknown origin (FUO) and anterior cervical adenopathy in a child

Article type: Research Article

Authors: Cunha, Burke A.^; | Durie, Nicole | Selbs, Elena | Weinblatt, Mark^; | McDermott, Brian P.^;

Affiliations: Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA | Department of Pathology, Winthrop-University Hospital, Mineola, NY, USA | Department of Pediatric Oncology, Winthrop-University Hospital, Mineola, NY, USA | State University of New York School of Medicine, Stony Brook, NY, USA

Note: [] Correspondence: Dr. Burke A. Cunha, M.D., Infectious Disease Division, Winthrop-University Hospital, Mineola, NY 11501, USA. Tel.: +1 516 663 2505; Fax: +1 516 663 2753; E-mail: [email protected]

Abstract: In children, cervical adenopathy and fever is a common diagnostic dilemma. We present an unusual case of fever with anterior cervical adenopathy mimicking lymphoma that was diagnosed by as Rosai-Dorfman disease (RD) by lymph node biopsy. RD disease typically presents in childhood with cervical adenopathy. Less commonly, RD may involve extra-nodal sites as well, including the skin (the most common extranodal site), central nervous system (CNS), eye, liver, spleen, pancreas, or kidney. Lymph node biopsy is diagnostic and to differentiates RD disease from other causes of lymphadenopathy such as lymphoma.

Keywords: FUO, mimics of lymphoma, sinus histiocytosis, lympadenopathy

DOI: 10.3233/JPI-2011-0297

Journal: Journal of Pediatric Infectious Diseases, vol. 6, no. 1, pp. 63-66, 2011