Moraxella catarrhalis: A mini review

Article type: Research Article

Authors: Hays, John P.

Affiliations: Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands

Note: [] Correspondence: John P. Hays, PhD, Department of Medical Microbiology and Infectious Diseases, Erasmus MC, `s Gravendijkwal 230, 3000 CA, Rotterdam, The Netherlands. Tel.: +44 10 7032177; Fax: +44 10 703875; E-mail: [email protected]

Abstract: Moraxella catarrhalis is a human-specific bacterium previously discounted as a simple commensal organism with only limited pathogenic potential. This view has changed considerably and we now know that M. catarrhalis is associated with a range of disease states affecting both children and adults. In particular, M. catarrhalis tends to be associated with upper respiratory tract infections, including otitis media and sinusitis in children and lower respiratory tract infections in adults with pre-existing pulmonary disease, e.g., exacerbations of chronic obstructive pulmonary disease. Colonization with this bacterium is especially common in infants and young children, the age group most affected by M. catarrhalis-mediated disease. Research is just beginning to unravel the complex interaction between this pathogen and the human host and is providing insights into its diverse genetic population structure and numerous virulence traits. These latter markers include multiple potential cellular adhesion molecules that are currently being researched as potential vaccine candidates. This mini-review is intended to provide the reader with a short introduction to M. catarrhalis as a pathogen and includes recent advances in the understanding of mechanisms associated with bacterial virulence.

Keywords: Moraxella catarrhalis, colonization, immune response, beta-lactamase

DOI: 10.3233/JPI-2009-0167

Journal: Journal of Pediatric Infectious Diseases, vol. 4, no. 3, pp. 211-220, 2009