Affiliations: Division of Pediatric Infectious Diseases, Duke
University Medical Center, Durham, NC, USA | Department of Pediatrics, Duke University Medical
Center, Durham, NC, USA
Note: [] Correspondence: Ravi Jhaveri, M.D., Division of Pediatric
Infectious Diseases, DUMC 3499, Durham, NC 27710, USA. Tel.: +1 919 684 6335;
Fax: +1 919 668 4859; E-mail: [email protected]
Abstract: The 7 valent conjugate pneumococcal vaccine (PCV7) has been shown to
have a broad impact on the rate of invasive pneumococcal disease in children as
well as the frequency of colonization and disease with other common respiratory
bacterial pathogens like Moraxella catarrhalis. This study investigated
whether these changes have translated to changes in M. catarrhalis
bacteremia. We screened all children with blood cultures performed at our
center in the years pre- (1997–1999) and post- (2001–2004) PCV7 institution.
There were six cases of M. catarrhalis bacteremia (pre-PCV7: 2,
post-PCV7: 4) or a rate of 11/10,000 blood cultures. PCV7 had no discernable
effect on frequency. In comparison to matched patients with Streptococcus
pneumoniae bacteremia, children with M. catarrhalis had lower fever and
white blood cell counts with better outcomes. There was no discernable change
in frequencies of M. catarrhalis bacteremia due to the introduction of
PCV7.
