Toll-like receptors; integrate innate and adaptive immunity, promise innovative therapies

Article type: Research Article

Authors: Yildiran, Alişan | İkincioǧullari,

Affiliations: Department of Pediatrics, Division of Allergy and Immunology, Faculty of Medicine, Ankara University, Ankara, Turkiye

Note: [] Correspondence: Alişan Yildiran, M.D., Yatıkmusluk Mh. Yatıkmusluk Cd. 11-E Blok, No 36, Gülveren, Ankara, Turkiye. Tel.: +90 312 362 08 77; Fax: +90 312 362 08 77; E-mail: [email protected]

Abstract: Innate component of immunity is a skilful system that senses invading microbial pathogens and integrates to adaptive immunity by Toll-like receptors (TLRs). Another function of TLRs is to work in sterile inflammation to ligands derived from damaged cells, which are not usually present in the extracellular environment. Thus, TLRs have very important interferences in the pathogenesis of inflammatory and immune diseases. The discovery of TLRs has transformed our approach to immunology and related diseases.

Keywords: Innate immunity, Toll-like receptors, NLR

Journal: Journal of Pediatric Infectious Diseases, vol. 1, no. 4, pp. 195-203, 2006