Affiliations: Department of Basic Sciences, Glycation, Oxidation and
Disease Laboratory, Touro University-California, Vallejo, CA, USA | Department of Clinical Pathology, Showa University
School of Medicine, Yokohama, Japan | Department of Obstetrics and Gynecology, Dokkyo
University School of Medicine, Tokyo, Japan
Note: [] Correspondence: Alejandro Gugliucci, MD, PhD, Glycation,
Oxidation and Disease Laboratory, Touro University California, 1310 Johnson
Lane, Vallejo, 94592, CA, USA. E-mail: [email protected]
Abstract: There is scarce information about altered aspirin – esterase (AE)
activities in various physiological and pathological states, as well as the
putative agents modulating this activity. Since there are no data on AE levels
in cord blood, we set up this study to measure its activity in neonates' cord
blood and in adults, using an optimized technique developed in our laboratory.
We performed a case-control study with 28 newborns, and control adult subjects
were selected from a healthy population of hospital workers. Aspirin esterase
activity in cord blood was 60 ± 12 nmol/mL/min vs 87
± 12 nmol/mL/min in adults, p <
0.00001. No correlation of AE activity and HDL cholesterol, HDL/LDL cholesterol
or paraoxonase 1 was found. Aspirin esterase correlated significantly with
serum cholinesterase: r=0.86 p <
0.0001, which was also 30% ower in cord blood than in adults. We show here,
for the first time, that cord blood serum has a significant aspirin esterase
activity, even though is its 40% lower than that found in adults. Our data
provide baseline information for future studies on the physiology of aspirin
esterase in children and the factors that modulate its activity to reach adult
levels.