Personality Related to Quality-of-Life Improvement After Deep Brain Stimulation in Parkinson’s Disease (PSYCHO-STIM II)

Article type: Research Article

Authors: Boussac, Mathilde^{a; *} | Arbus, Christophe^b | Klinger, Helene^c | Eusebio, Alexandre^d | Hainque, Elodie^e | Corvol, Jean Christophe^f | Rascol, Olivier^{a; g} | Rousseau, Vanessa^g | Harroch, Estelle^g | d’Apollonia, Charlotte Scotto^g | Croiset, Aurélie^h | Ory-Magne, Fabienne^{a; g} | De Barros, Amaury^{a; i} | Fabbri, Margherita^{a; g} | Moreau, Caroline^j | Rolland, Anne-Sophie^j | Benatru, Isabelle^k | Anheim, Mathieu^l | Marques, Ana-Raquel^m | Maltête, Davidⁿ | Drapier, Sophie^o | Jarraya, Béchir^p | Hubsch, Cécile^q | Guehl, Dominique^{r; s} | Meyer, Mylène^t | Rouaud, Tiphaine^u | Giordana, Bruno^v | Tir, Mélissa^w | Devos, David^j | Brefel-Courbon, Christine^{a; g} | for the PREDISTIM study group

Affiliations: [a] Toulouse Neuro Imaging Center, University of Toulouse, Inserm, UPS, France | [b] Psychiatry Department of the University Hospital of Toulouse, CHU Purpan, Toulouse, France | [c] Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France | [d] Aix Marseille Université, AP-HM, Hôpital de La Timone, Service de Neurologie et Pathologie du Mouvement, and UMR CNRS, Institut de Neuroscience de La Timone, NS-PARK/FCRIN Network, Marseille, France | [e] Département de Neurologie, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France et Faculté de Médecine de Sorbonne Université, Paris, France | [f] Sorbonne Université, Paris Brain Institute –ICM, Inserm, CNRS, Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, NS-PARK/FCRIN, Department of Neurology, Paris, France | [g] Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Center, Clinical Investigation Center, University Hospital of Toulouse, NeuroToul COEN (Center of Excellence in Neurodegeneration), Toulouse, NS-PARK/FCRIN Network, France | [h] CERPPS—Study and Research Center in Psychopathology and Health Psychology, University of Toulouse II Jean-Jaurès, Toulouse, France | [i] Department of Neurosurgery, Toulouse University Hospital, Toulouse, France | [j] Department of Medical Pharmacology, Neurology and Movement Disorders Department, Referent center of Parkinson’s disease, CHU of Lille, Univ. Lille Neuroscience & Cognition, Inserm, UMR-S1172, Licend, Lille, NS-PARK/FCRIN Network, France | [k] Neurology Department, University Hospital of Poitiers, Poitiers, France; INSERM, CHU de Poitiers, University of Poitiers, Centre d’Investigation Clinique CIC1402, Poitiers, France | [l] Service de Neurologie, Hôpitaux Universitaires de Strasbourg; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM-U964/CNRS-UMR7104/Université de Strasbourg, Illkirch; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France | [m] Université Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand University Hospital, Neurology department, France | [n] Department of Neurology, Rouen University Hospital and University of Rouen, France; INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Mont-Saint-Aignan, France | [o] CHU Rennes, Service de neurologie, CIC-INSERM 1414, Rennes, France | [p] Pôle Neurosciences, Foch Hospital, Suresnes; Université Paris-Saclay, UVSQ, INSERM U992, CEA Paris-Saclay, Neurospin, France | [q] Hôpital Fondation A de Rothschild, Service de recherche clinique, Paris, France | [r] Institut des Maladies Neurodégénératives (IMN, CNRS U5393), Université de Bordeaux, Bordeaux, France | [s] Service de Neurophysiologie Clinique, Pôle des Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France | [t] Service de neurologie, Hôpital Central, CHRU de Nancy, Nancy Cedex, France | [u] Clinique Neurologique, Hôpital Guillaume et René Laennec, Boulevard Jacques Monod, Nantes Cedex, France | [v] CHU Nice, Department of Psychiatry and Psychotherapy, Nice, France | [w] Department of Neurology, Department of Neurosurgery, Expert Centre for Parkinson’s disease, Amiens University Hospital, EA 4559 Laboratoire de Neurosciences Fonctionnelles et Pathologie (LNFP) Université de Picardie Jules Verne, University of Picardy Jules Verne (UPJV), NS-PARK/FCRIN Network, Amiens, France

Correspondence: [*] Correspondence to: Mathilde Boussac, PhD Student, Unité ToNIC, Toulouse NeuroImaging Center, UMR 1214 –INSERM/UPS –CHU PURPAN –Pavillon Baudot, Place du Dr Baylac, 31024 Toulouse, France. Tel.: +33 05 62 74 61 99; E-mail: [email protected].

Abstract: Background:Deep brain stimulation of the sub-thalamic nucleus (DBS-STN) reduces symptoms in Parkinson’s disease (PD) patients with motor fluctuations. However, some patients may not feel ameliorated afterwards, despite an objective motor improvement. It is thus important to find new predictors of patients’ quality of life (QoL) amelioration after DBS-STN. We hypothesized that personality dimensions might affect QoL after DBS-STN. Objective:To evaluate associations between personality dimensions and QoL improvement one year after DBS-STN. Methods:DBS-STN-PD patients (n = 303) having answered the “Temperament and Character Inventory” (TCI) before surgery and the PDQ-39 before and one year after surgery were included, from the cohort study PREDI-STIM. Linear regression models were used to evaluate associations between TCI dimensions and change in PDQ-39 scores after DBS-STN. Results:Novelty Seeking and Cooperativeness scores before surgery were positively associated with PDQ-39 scores improvement after DBS-STN (FDR-adjusted p < 0.01). Moreover, paradoxically unimproved patients with deterioration of their PDQ-39 scores after DBS-STN despite improvement of their MDS-UPDRS-IV scores had lower Cooperativeness scores, while paradoxically improved patients with amelioration of their PDQ-39 scores despite deterioration of their MDS-UPDRS-IV scores had higher Reward Dependence scores. Conclusion:Some presurgical personality dimensions were significantly associated with QoL amelioration and discrepancy between motor state and QoL changes after DBS-STN in PD. Educational programs before DBS-STN should take in account patient personality dimensions to better deal with their expectations.

Keywords: Cooperativeness, DBS-STN, novelty seeking, Parkinson’s disease, quality of life

DOI: 10.3233/JPD-212883

Journal: Journal of Parkinson's Disease, vol. 12, no. 2, pp. 699-711, 2022