Affiliations: [a] Center for Movement Studies, Kennedy Krieger Institute, Baltimore, MD, USA
| [b] Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
| [c] Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
| [d] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
| [e] Departmentof Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Correspondence:
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Correspondence to: Ryan T. Roemmich, PhD, G-04 Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA. E-mail: [email protected].; Twitter: @RyanRoemmich
Abstract: Background:Gait slowing is a common feature of Parkinson’s disease (PD). Many therapies aim to improve gait speed in persons with PD, but goals are often imprecise. How fast should each patient walk? And how do persons with PD benefit from walking faster? There is an important need to understand how walking speed affects fundamental aspects of gait—including energy cost and stability—that could guide individualized therapy decisions in persons with PD. Objective:We investigated how changes in walking speed affected energy cost and spatiotemporal gait parameters in persons with PD. We compared these effects between dopaminergic medication states and to those observed in age-matched control participants. Methods:Twelve persons with PD and twelve control participants performed treadmill walking trials spanning at least five different speeds (seven speeds were desired, but not all participants could walk at the fastest speeds). Persons with PD participated in two walking sessions on separate days (once while optimally medicated, once after 12-hour withdrawal from dopaminergic medication). We measured kinematic and metabolic data across all trials. Results:Persons with PD significantly reduced energy cost by walking faster than their preferred speeds. This held true across medication conditions and was not observed in control participants. The patient-specific walking speeds that reduced energy cost did not significantly affect gait variability metrics (used as proxies for gait stability). Conclusion:The gait slowing that occurs with PD results in energetically suboptimal walking. Rehabilitation strategies that target patient-specific increases in walking speed could result in a less effortful gait.
