Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Senkevich, Konstantina; b | Bandres-Ciga, Sarac | Yu, Erica; d | Liyanage, Upekha E.e | International Parkinson Disease Genomics Consortium (IPDGC) | Noyce, Alastair Jf; g | Gan-Or, Ziva; b; d; *
Affiliations: [a] The Neuro (Montreal Neurological Institute-Hospital), Montréal, QC, Canada | [b] Department of Neurology and neurosurgery, McGill University, Montréal, QC, Canada | [c] Molecular Genetics Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD, USA | [d] Department of Human Genetics, McGill University, Montréal, QC, Canada | [e] Cancer and Population Studies group, Population Health Department, QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Queensland, Australia | [f] Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK | [g] Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, London, UK
Correspondence: [*] Correspondence to: Ziv Gan-Or, MD, PhD, Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue, West, Ludmer Pavilion, room 312, Montreal, QC, H3A 1A1, Canada. Tel.: +1 514 398 5845; Fax: +1 514 398 8248; E-mail: [email protected].
Abstract: Background:Epidemiological data suggest that cancer patients have a reduced risk of subsequent Parkinson’s disease (PD) development, but the prevalence of PD in melanoma patients is often reported to be increased. Causal relationships between cancers and PD have not been fully explored. Objective:To study causal relationship between different cancers and PD. Methods:We used GWAS summary statistics of 15 different types of cancers and two-sample Mendelian randomization to study the causal relationship with PD. Results:There was no evidence to support a causal relationship between the studied cancers and PD. We also performed reverse analyses between PD and cancers with available full summary statistics (melanoma, breast, prostate, endometrial and keratinocyte cancers) and did not find evidence of causal relationship. Conclusion:We found no evidence to support a causal relationship between cancers and PD and the previously reported associations could be a result of genetic pleiotropy, shared biology or biases.
Keywords: Parkinson’s disease, mendelian randomization, cancer, melanoma
DOI: 10.3233/JPD-202474
Journal: Journal of Parkinson's Disease, vol. 11, no. 2, pp. 801-809, 2021
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]