Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Ghosh, Prithaa; 1 | Imbriani, Paolab; c; 1 | Caputi, Nicolettab | Natoli, Silviad | Schirinzi, Tommasob | Di Lazzaro, Giuliab | Covington, Lindseya | Sparks, Andrew D.a | Salnikova, Yekaterinaa | Rukavina, Katarinae; f | Ray Chaudhuri, K.e; f | Pisani, Antoniob; c; *
Affiliations: [a] Department of Neurology, Medical Faculty Associates, George Washington University, Washington, DC, USA | [b] Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy | [c] IRCCS Fondazione Santa Lucia, Rome, Italy | [d] Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy | [e] King’s College London, Department of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, De Crespigny Park, London, United Kingdom | [f] Parkinsons Foundation Centre of Excellence, King’s College Hospital, London, United Kingdom
Correspondence: [*] Correspondence to: Antonio Pisani, MD, PhD, Department of Systems Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy. Tel.: +39 0672596010; Fax: +39 0672596006; E-mail: [email protected].
Note: [1] These authors contributed equally to this work
Abstract: Background:Pain is a disabling and often underestimated non-motor symptom (NMS) detrimentally affecting the quality of life of patients with Parkinson’s disease (PD). Objective:Here, we conducted a cross-sectional, observational international study on 167 patients with idiopathic PD in order to analyze the potential relationship between pain and other NMS. Methods:Subjects were assessed with the Unified Parkinson’s Disease Rating Scale (UPDRS) part III, Hoehn and Yahr (H&Y) stage, King’s Parkinson’s Disease Pain Scale (KPPS), Brief Pain Inventory (BPI), Non-Motor Symptoms Scale (NMSS), and Beck Depression Inventory (BDI). Spearman’s rank correlation coefficient, multiple regression and multiple index-based clustering algorithms were used for data analysis. Results:The prevalence of pain was 88.6%, was not correlated with age, motor severity (UPDRS part III) or disease duration, whereas a weak correlation with female gender and H&Y stage >2.5 was found. Multiple NMS correlated significantly with pain. Specifically, sleep disturbance had the strongest correlation with pain, followed by depression, gastrointestinal and cardiovascular disturbances. Further analyses showed that sleep and cardiovascular disturbance were independently associated with pain, and that these symptoms clustered together in a subset of PD patients. The relationship between pain, sleep and dysautonomia persisted independently from dopamine replacement therapy. Conclusion:Our study suggests that sleep disruption and cardiovascular disturbance are associated with pain in PD, and possibly identifies a specific subtype within PD patients with pain. Our data also indicate that sleep disruption, pain and dysautonomia may have a common pathophysiology, possibly involving non-dopaminergic pathways.
Keywords: Neurodegeneration, noradrenergic pathway, pain, parkinsonism, serotonergic pathway
DOI: 10.3233/JPD-202088
Journal: Journal of Parkinson's Disease, vol. 10, no. 4, pp. 1817-1825, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]