Affiliations: [a] Department of Orthopedics, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
| [b] Department of Dermatology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
| [c] Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Correspondence:
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Correspondence to: Young Bok Lee, MD, PhD, Department of Dermatology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Gyeonggi-Do, Korea. 271, Cheon Bo-ro, Uijeongbu, Gyeonggi-Do, 07345, Republic of Korea. Tel.: +82 31 820 3509; Fax: +82 31 846 4799; E-mail: [email protected].
Abstract: Background:Although several studies have reported a correlation between Behçet’s disease (BD) and Parkinson’s disease, this association has not yet been clarified. Objective:To determine the risk of Parkinson’s disease in patients with BD. Methods:BD patients (n = 17,179; mean age, 51.12±8.09 years; male, 34.95%) without known previous diagnosis of Parkinson’s disease were selected from the Korean National Health Insurance Database between 2010 and 2013. An age- and gender-matched control population of individuals without BD was randomly sampled at a ratio of 3:1 (n = 34,575). Both cohorts were followed for development of Parkinson’s disease until 2015. Results:Among a total of 11,525 BD patients, 50 (0.43%) developed Parkinson’s disease, whereas only 51 among the 34,575 individuals in the non-BD group developed Parkinson’s (0.15%, P < 0.0001). The incidence of Parkinson’s disease was significantly higher in BD patients than in controls. In addition, during the follow-up period, patients with BD were more likely to be diagnosed with Parkinson’s disease than those in the non-BD group. Conclusions:BD patients had a higher risk of Parkinson’s disease compared to non-BD controls. Physicians should carefully monitor patients with BD for potential development of Parkinson’s disease.
