Affiliations: [a] Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany
| [b] Department of Neurology, University of Rostock, Rostock, Germany
| [c] Movement Disorders Clinic, Beelitz-Heilstätten, Germany
| [d] Department of Neurology, Klinikum Bremerhaven, Bremerhaven, Germany
| [e] Department of Neurology, University Hospital, Lund, Sweden
| [f] Parkinson Clinic Wolfach, Wolfach, Germany
| [g] National Parkinson Foundation Centre of Excellence, Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, UK
| [h] Department of Medical Informatics and Biometry, Technische Universität Dresden, Dresden, Germany
| [i] German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany
Correspondence:
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Correspondence to: Alexander Storch, M.D., Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany. Tel.: +49 381 494 9510; Fax: +49 381 494 9512; E-mail: [email protected]
Abstract: Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson’s disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient variability in frequency and severity of NMS during a series of five patient-perceived motor On and Off periods in 38 fluctuating PD patients from the multicenter NonMotorFluctuations in PD study using a visual analogue scale. NMS frequency and severity appeared moderately variable in both motor states within individual patients. Symptom severity ranges between motor states showed high variability and were larger in motor Off states for most NMS.
