Chronic Subcutaneous Infusion Therapy with Apomorphine in Advanced Parkinson's Disease Compared to Conventional Therapy: A Real Life Study of Non Motor Effect
Affiliations: Alzheimer Disease Research Unit and CIBERNED, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain | Department for Parkinson's disease, IRCCS San Camillo, Venice, Italy | Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark | Department of Neurology, SMZ-Ost Donauspital, Vienna, Austria | Department of Neurology, Central Hospital, Bremerhaven, Germany | Department of Neurology, NPF Centre of Excellence, King's College Hospital, MRC Centre for Neurodegeneration Research and Biomedical Research Centre, Kings College, London, United Kingdom | University Hospital Lewisham, London, UK
Note: [] Correspondence to: Prof. K. Ray Chaudhuri, Department of Neurology, King's College Hospital, Denmark Hill, SE5 9RS London, UK. E-mail: [email protected]
Abstract: Background: Apomorphine infusion therapy remains under-used and there are no comparative studies of motor and non-motor effects of apomorphine infusion. Methods: In this paper we report preliminary results from an ongoing clinical observational “real life” surveillance-based study focused on effects of this therapy on non-motor symptoms and health-related quality of life in a group of patients on apomorphine. Results: Apomorphine infusion led to highly significant improvements in UPDRS 3 (p = 0.0003), UPDRS 4 (p = 0.0003), PDQ-8 (Parkinson's disease questionnaire, p = 0.001) and NMSS total (non motor symptoms scale, p = 0.0003). Furthermore, apomorphine was tolerated in patients with visual hallucinations, illusions and paranoid ideations while significant improvement in specific non-motor symptoms such as hyperhidrosis, nocturia, urgency of micturition, and fatigue was recorded. Levodopa equivalent dose decreased significantly (1077.81 ± 446.26 to 458.75 ± 282.29, p < 0.0001) and a large effect size of intervention was noted. In an untreated group no such improvement was noted. The number needed to treat (NNT) for improvement >1 SEM in the Apo group was calculated and was lower than 2 for >1 SEM improvement of UPDRS 3, NMSS, and PDQ-8 total scores. Conclusions: This pilot observational study suggests that non-motor effects are evident with apomorphine therapy and patients suitable for apomorphine deteriorate in the absence of therapy.
