Affiliations: Parkinson's disease and Movement Disorders Unit, Hospital de Clinicas “Jose de San Martin”, University of Buenos Aires, Buenos Aires, Argentina | Department of Neurology, Mayo Clinic. Rochester, MN, USA
Note: [] Correspondence to: Maria G. Cersósimo, MD, Parkinson's disease and Movement Disorders Unit, Hospital de Clinicas “Jose de San Martin”, University of Buenos Aires, Buenos Aires, Argentina. Tel.: 5411 5950 9021; Fax: 5411 4806 2217; E-mail: [email protected]
Abstract: There is involvement of salivary glands by α-synuclein pathology in PD. However, the prevalence of dry mouth has not been systematically assessed in these patients. We studied 97 PD patients and 86 controls using a structured questionnaire. Dry mouth was reported by 60.8% of PD patients and 27.9% of controls (p < 0.0001). Dry mouth and drooling coexisted in 30% of cases. Only 12% of patients had reported dry mouth to their physicians. Dry mouth is a frequent but underreported symptom and may be an early manifestation of autonomic involvement in PD.
