Serum Acetylcholine Receptor Antibodies Before the Clinical Onset of Myasthenia Gravis

Article type: Case Report

Authors: Strijbos, Ellen^{a; *} | Verschuuren, Jan J.G.M.^a | Kuks, Jan B.M.^b

Affiliations: [a] Department of Neurology, Leiden University Medical Centre, The Netherlands | [b] Department of Neurology, University Medical Centre of Groningen, The Netherlands

Correspondence: [*] Correspondence to: Ellen Strijbos, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. Tel.: +31 71 5262118; Fax: +31 71 5266671; E-mail: [email protected].

Abstract: A patient with autoimmune myasthenia gravis and a clinical and serological follow-up of 13 years is described. In this unique case, serum samples were available up to two years before the clinical onset of the myasthenia gravis and showed gradual increase of acetylcholine receptor antibodies, starting two years before onset of the clinical symptoms.

Keywords: Myasthenia gravis, pregnancy, acetylcholine receptor antibodies, neuroimmunology

DOI: 10.3233/JND-180313

Journal: Journal of Neuromuscular Diseases, vol. 5, no. 2, pp. 261-264, 2018