Expanding the Clinical Spectrum of IgLON5-Syndrome

Article type: Brief Report

Authors: Wenninger, Stephan^{; *}

Affiliations: Friedrich-Baur-Institute, Department of Neurology of the University of Munich, Munich, Germany

Correspondence: [*] Correspondence to: Dr. med. Stephan Wenninger, Friedrich-Baur-Institute, Department of Neurology of the University of Munich, Ziemssenstr. 1a, 80336 Munich, Germany. Tel.: +49 0 894400 57470; Fax: +49 0 894400 57402; E-mail: [email protected].

Abstract: Anti-IgLON5-syndrome is known to be an antibody-mediated disease that mainly affects central structures in tegmentum and hippocampus and leads to associated symptoms like sleep-related disturbances, parkinsonism, chorea and limb ataxia. This is the first case of a patient with anti-IgLON5-syndrome and generalized fasciculations and neuromyotonic discharges in electromyography, suggesting that a peripheral involvement may occur in anti-Ig-Lon5-syndromes.

Keywords: Neuromyotonia, neuroimmunology, anti-IgLON5-syndrome, fasciculations, dysphagia

DOI: 10.3233/JND-170259

Journal: Journal of Neuromuscular Diseases, vol. 4, no. 4, pp. 337-339, 2017